产品详情
产品名称DENND1B Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification
应用IHC
种属反应性Human
特异性The antibody detects endogenous levels of total DENND1B protein.
免疫原类型protein
免疫原描述Fusion protein of human DENND1B
基因/蛋白名称DENND1B
标记Unconjugated
别名FAM31B; C1ORF18; C1orf218
数据库入口号Swiss-Prot#:Q6P3S1
NCBI Gene ID:163486
Gene Accssion:BC022561
Uniprot
Q6P3S1
浓度0.7mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20C
应用详情
Immunofluorescence:1: 20-100
The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 47045(DENND1B Antibody) at dilution 1/20. (Original magnification: ?00)
The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using 47045(DENND1B Antibody) at dilution 1/20. (Original magnification: ?00)
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).
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