产品详情
产品名称Protein FAM38A Antibody
克隆号2018/2/10
来源种属Mouse
克隆性Monoclonal
纯化ProA affinity purified
应用WB, IHC, ICC
种属反应性Human;Mouse
免疫原描述Recombinant protein.
标记Unconjugated
别名DHS
Fam38a
Family with sequence similarity 38 member A
KIAA0233
Membrane protein induced by beta-amyloid treatment
Mib
PIEZ1_HUMAN
Piezo-type mechanosensitive ion channel component 1
PIEZO1
Protein FAM38A
Protein FAM38B
Protein PIEZO1
数据库入口号Swiss-Prot#:Q92508
Uniprot
Q92508
计算分子量287 kDa
配方1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB 1:500-1:2000； IHC 1:200-1:600； ICC 1:100；
Western blot analysis of FAM38A on MCF-7 cell lysates with Mouse anti-FAM38A antibody at 1/500 dilution.
Immunocytochemistry analysis of Hela cells with FAM38A at 1/100 dilution.
Immunocytochemistry analysis of A431 cells with FAM38A at 1/100 dilution.
Immunohistochemical analysis of paraffin-embedded mouse brain tissue with FAM38A at 1/200 dilution.
Immunohistochemical analysis of paraffin-embedded rat brain tissue with FAM38A at 1/600 dilution.
Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.
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et al,Impaired AT2 to AT1 cell transition in PM2.5-induced mouse model of chronic obstructive pulmonary disease. In Respir Res on 2022 Mar 25 by Hongjiao Yu, Yingnan Lin,et al..PMID:35337337
, (2022),
PMID:
35337337
Yes
