产品详情
产品名称IGF1R Antibody
来源种属Rabbit
克隆性Polyclonal
纯化ProA affinity purified
应用WB;IHC
种属反应性Human
免疫原描述peptide
标记Unconjugated
别名CD221 antibody CD221 antigen antibody IGF 1 receptor antibody IGF 1R antibody IGF I receptor antibody IGF-I receptor antibody Igf1r antibody IGF1R_HUMAN antibody IGFIR antibody IGFIRC antibody IGFR antibody Insulin like growth factor 1 receptor antibody Insulin like growth factor 1 receptor precursor antibody Insulin-like growth factor 1 receptor beta chain antibody Insulin-like growth factor I receptor antibody JTK13 antibody MGC142170 antibody MGC142172 antibody MGC18216 antibody Soluble IGF1R variant 1 antibody Soluble IGF1R variant 2 antibody
数据库入口号Swiss-Prot#:P08069
Uniprot
P08069
计算分子量154 kDa
实际分子量95kDa
配方1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:50-1:300;
Western blot analysis of extracts from various cells using IGF1R Antibody.
Western blot analysis of extracts from Hela and A375 cells using IGF1R Antibody.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti- IGF1R rabbit polyclonal antibody.
Immunohistochemistry analysis of paraffin-embedded human brain tissue using IGF1R Antibody.
Immunohistochemistry analysis of paraffin-embedded Human liver cancer tissue using IGF1R Antibody.
Immunofluorescence staining of MCF-7 cells with IGF1R Antibody , counter-stained with DAPI.
Immunofluorescent analysis of IGF1R Antibody staining in HeLa cells.
Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis.
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et al,Investigating Serum and Placental Levels of IGF-1 and IGF-1R in Preeclampsia Patients and Their Clinical Implications.
, (2025),
PMID:
40099233
Yes
