产品详情
产品名称Caspase 12 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Immunogen affinity purified
应用WB, IP, IF
种属反应性Human;Mouse;Rat
免疫原描述peptide
标记Unconjugated
别名CASP 12 antibody CASP-12 antibody Casp12 antibody CASP12P1 antibody caspase 12 (gene/pseudogene) antibody caspase 12 pseudogene 1 antibody CASPC_HUMAN antibody Inactive caspase-12 antibody OTTHUMP00000207032 antibody
数据库入口号Swiss-Prot#:O08736
Uniprot
O08736
计算分子量50kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:100-1,000
IP: 1-2 ug per 100-500 ug of total protein (1ml of cell lysate)
Western blot analysis of caspase-12 expression in BC3H1 (A) and UV-treated NIH/3T3 (B) whole cell lysates.
Immunofluorescence staining of methanol-fixed BC3H1 cells showing cytoplasmic localization.
A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed Ced-3/caspase-1, is composed of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6 and caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9, caspase-10, caspase-14, and caspase-5/caspase-12. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-5 (also designated TY or ICErelIII) can cleave its own precursor, an activity that requires the cysteine 245 residue. The mouse homolog of caspase-5 is designated caspase-12. Frameshift mutations in caspase-5 have been identified in MMP tumors of the endometrium, colon, and stomach, indicating that caspase-5 may be a new target gene in the microsatellite mutator pathway for cancer.
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et al,5鈥慛itro锟?锟?3鈥憄henylpropylamino) benzoic acid induces apoptosis of human lens epithelial cells via reactive oxygen species and endoplasmic reticulum stress through the mitochondrial apoptosis pathway. In Int J Mol Med on 2021 Apr by Lingzhi Niu, Xin Liu,et al..PMID:33604681
, (2021),
PMID:
33604681
Yes
