产品详情
产品名称FOXM1 Antibody
克隆号4G1
来源种属Mouse
纯化ProA affinity purified
应用WB, IP, IF
种属反应性Human;Mouse;Rat
免疫原描述peptide
标记Unconjugated
别名FKHL16 antibody Forkhead box M1 antibody Forkhead box protein M1 antibody forkhead like 16 antibody Forkhead-related protein FKHL16 antibody FOX M1 antibody Foxm1 antibody FOXM1_HUMAN antibody FOXM1B antibody Hepatocyte nuclear factor 3 forkhead homolog 11 antibody HFH-11 antibody HFH11 antibody HNF-3/fork-head homolog 11 antibody HNF3 antibody INS1 antibody M phase phosphoprotein 2 antibody M-phase phosphoprotein 2 antibody MPHOSPH2 antibody MPM-2 reactive phosphoprotein 2 antibody MPP2 antibody PIG29 antibody TGT3 antibody Transcription factor Trident antibody Trident antibody WIN antibody Winged-helix factor from INS-1 cells antibody Winged-helix factor from INS1 cells antibody
数据库入口号Swiss-Prot#:Q08050
Uniprot
Q08050
计算分子量83 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at 4˚C
应用详情
WB: 1:100-1:1,000
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
The Fox family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. FOXM1, also known as FKHL16, MPP2 or Trident, is primarily expressed in proliferating cells. The gene encoding human FOXM1 maps to chromosome 12p13. The transcription element that restricts FOXM1 expression to proliferating cells is located 300 bp upstream of the start codon. FOXM1 is most abundant in thymus, testis, small intestine and colon. Alternative splicing generates FOXM1A and FOXM1B isoforms that contain PEST regions involved in rapid protein degradation. A decrease in FOXM1 expression is associated with age-related defects in cellular proliferation. Conversely, an increase in FOXM1B expression in the livers of older transgenic mice restore hepatocyte DNA replication rates to the higher rate present in young livers. FOXM1B activates the transcription of cyclin B1, cyclin D1 and Cdc25B.
Yes
