产品详情
产品名称NGF beta Antibody
克隆号1G4
来源种属Mouse
纯化ProA affinity purified
应用WB, IP, IF
种属反应性Human;Mouse;Rat
免疫原描述Amino acids 122-149 at the N-terminus of mature NGF of human origin.
标记Unconjugated
别名Beta nerve growth factor antibody Beta NGF antibody Beta-nerve growth factor antibody Beta-NGF antibody HSAN5 antibody MGC161426 antibody MGC161428 antibody Nerve growth factor (beta polypeptide) antibody Nerve growth factor antibody Nerve growth factor beta antibody Nerve growth factor beta polypeptide antibody Nerve growth factor beta subunit antibody NGF antibody NGF_HUMAN antibody NGFB antibody NID67 antibody
数据库入口号Swiss-Prot#:P01138
Uniprot
P01138
计算分子量27kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at 4˚C
应用详情
WB: 1:100-1:1,000
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
Neurotrophins function to regulate naturally occurring cell death of neurons during development. The prototype neurotrophin is nerve growth factor (NGF), originally discovered in the 1950s as a soluble peptide promoting the survival of, and neurite outgrowth from, sympathetic ganglia. Three additional structurally homologous neurotrophic factors have been identified. These include brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) (also designated NT-5). These various neurotrophins stimulate the in vitro survival of distinct, but partially overlapping, populations of neurons. The cell surface receptors through which neurotrophins mediate their activity have been identified. For instance, the Trk A receptor is the preferential receptor for NGF, but also binds NT-3 and NT-4. The Trk B receptor binds both BDNF and NT-4 equally well, and binds NT-3 to a lesser extent, while the Trk C receptor only binds NT-3.
Yes
