产品详情
产品名称YAP1 Antibody
克隆号3G1
来源种属Mouse
纯化ProA affinity purified
应用WB, IP, IF
种属反应性Human;Mouse;Rat
免疫原描述Amino acids 294-323 within an internal region of YAP of human origin.
标记Unconjugated
别名65 kDa Yes associated protein antibody 65 kDa Yes-associated protein antibody COB1 antibody YAp 1 antibody YAP 65 antibody YAP antibody YAP1 antibody YAP1_HUMAN antibody YAP2 antibody YAP65 antibody yes -associated protein delta antibody Yes associated protein 1 65kDa antibody Yes associated protein 1 antibody Yes associated protein 2 antibody yes associated protein beta antibody YKI antibody Yorkie homolog antibody
数据库入口号Swiss-Prot#:P46937
Uniprot
P46937
计算分子量65kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at 4˚C
应用详情
WB: 1:100-1:1,000
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
The Yes-associated protein, otherwise known as YAP, is a 14-3-3-bindingmolecule that was originally recognized by virtue of its ability to bind to theSH3 domain of Yes. The binding of YAP to 14-3-3 requires the phosphorylationof a homologous serine residue (Ser 112) in the YAP 14-3-3-binding motif. Thehighly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation,cell cycle progression and apoptosis by binding intracellular phosphoproteinsinvolved in signal transduction. YAP may link events at the plasmamembrane and cytoskeleton to inhibition of transcription in the nucleus in amanner regulated by 14-3-3 proteins. YAP shares homology with the WWdomain of TAZ, transcriptional co-activator with PDZ-binding motif, whichfunctions as a transcriptional co-activator by binding to the PPXY motif presentin transcription factors. YAP is expressed at high levels in the lung, placenta,prostate, ovary and testis.
Yes
