产品详情
产品名称NF-κB p65 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Peptide affinity purified
应用WB;IHC;FC
种属反应性Human;Mouse;Rat
免疫原描述This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to N-terminal NF-κB p65.
标记Unconjugated
别名Avian reticuloendotheliosis viral (v rel) oncogene homolog A antibody
MGC131774 antibody
NF kappa B p65delta3 antibody
NFKB3 antibody
Nuclear Factor NF Kappa B p65 Subunit antibody
Nuclear factor NF-kappa-B p65 subunit antibody
Nuclear factor of kappa light polypeptide gene enhancer in B cells 3 antibody
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 antibody
OTTHUMP00000233473 antibody
OTTHUMP00000233474 antibody
OTTHUMP00000233475 antibody
OTTHUMP00000233476 antibody
OTTHUMP00000233900 antibody
p65 antibody
p65 NF kappaB antibody
p65 NFkB antibody
relA antibody
TF65_HUMAN antibody
Transcription factor p65 antibody
v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)) antibody
V rel avian reticuloendotheliosis viral oncogene homolog A antibody
v rel reticuloendotheliosis viral oncogene homolog A (avian) antibody
V rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B cells 3, p65 antibody
数据库入口号Swiss-Prot#:Q04206
Uniprot
Q04206
计算分子量65 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-1:2,000
IHC: 1:100-1:200
FC: 1:50-1:100
Western blot analysis of lysates from various cell lines using NFkB-p65 Antibody. Lane1: Hela Lane2:A549 Lane3: PC12 Lane 4: Mouse embryonic stem cell Lane5: NIH/3T3
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-NF-κB p65 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using anti-NF-κB p65 antibody. Counter stained with hematoxylin.
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins. NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression.
如果您使用该产品48498发表了文章，请通知我们，让我们可以引用您的文献。
et al,Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells. In Toxicol Appl Pharmacol on 2020 Oct 1 by Yuwen Sheng, Zhonghui Zhang, et al..PMID:32822738
, (2020),
PMID:
32822738
et al,Effect of Fushengong Decoction on PTEN/PI3K/AKT/NF-KB Pathway in Rats With Chronic Renal Failure via Dual-Dimension Network Pharmacology Strategy.In Front Pharmacol on 2022 Mar 15 by Hongyu Luo, Munan Wang,et al..PMID: 35370667
, (2022),
PMID:
35370667
et al,Resveratrol attenuates cigarette smoke extract induced cellular senescence in human airway epithelial cells by regulating the miR-34a/SIRT1/NF-κB pathway. In Medicine (Baltimore) on 2022 Nov 18 by Xiao-Li Zeng, Xin-Na Yang, et al..PMID: 36401446
, (2022),
PMID:
36401446
et al,Effect of Fushengong Decoction on PTEN/PI3K/AKT/NF-κB Pathway in Rats With Chronic Renal Failure via Dual-Dimension Network Pharmacology Strategy. In Front Pharmacol on 2022 Mar 15 by Hongyu Luo, Munan Wang, et al..PMID: 35370667
, (2022),
PMID:
35370667
et al,A multi-omics approach based on 1H-NMR metabonomics combined with target protein analysis to reveal the mechanism of RIAISs on cervical carcinomaIn Aging (Albany NY)On2022 Sep 27byChai Yanlan , Aibibai Jielili et al..PMID:36170024
, (2023),
PMID:
36170024
et al,Aurantio-obtusin Alleviates Dry Eye Disease by Targeting NF-κB/NLRP3 Signaling in Rodent Models
, (2023),
PMID:
et al,Mannose-modified multifunctional iron-based nanozyme for hepatocellular carcinoma treatment by remodeling the tumor microenvironment.
, (2025),
PMID:
39923382
查看更多
et al,A multi-omics approach based on ¹H-NMR metabonomics combined with target protein analysis to reveal the mechanism of RIAISs on cervical carcinoma patients
, (2023),
PMID: 36170024
et al,Identification of Cytochrome P450 2E1 as a Novel Target in Neuroinflammation and Development of Its Inhibitor Q11 as a Treatment Strategy.
, (2025),
PMID: 40122152
et al,Phellodendrine Exerts Protective Effects on Intra-abdominal Sepsis by Inactivating AKT/NF-kB Signaling.
, (2025),
PMID: 39953352
Yes
