产品详情
产品名称GRP78 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Peptide affinity purified
应用WB;ICC;IHC;FC
种属反应性Human;Mouse;Rat
免疫原描述peptide
标记Unconjugated
别名78 kDa glucose regulated protein antibody
78 kDa glucose-regulated protein antibody
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D2Wsu17e antibody
Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 antibody
Endoplasmic reticulum lumenal Ca2+ binding protein grp78 antibody
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Glucose Regulated Protein 78kDa antibody
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Heat shock 70 kDa protein 5 antibody
Heat Shock 70kDa Protein 5 antibody
Heat shock protein family A (Hsp70) member 5 antibody
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mBiP antibody
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数据库入口号Swiss-Prot#:P11021
Uniprot
P11021
计算分子量78kDa
实际分子量72-78kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:2,000
IHC: 1:200
ICC: 1:200
FC: 1:100-1:200
Western blot analysis of extracts from various cell lines using GRP78 antibody.
Immunohistochemical analysis of paraffin-embedded rat small intestine tissue using GRP78 Antibody.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using GRP78 Antibody.
Immunohistochemical analysis of paraffin-embedded mouse lung tissue using GRP78 Antibody.
Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using GRP78 Antibody.
Immunofluorescence analysis of Hela cells (green) using GRP78 Antibody.
Immunofluorescence analysis of SK-BR-3 cells (green) using GRP78 Antibody.
Immunofluorescence analysis of HepG2 cells (green) using GRP78 Antibody.
Immunofluorescence analysis of Hela cells (green) using GRP78 Antibody.Blue: DAPI for nuclear staining.
Binding immunoglobulin protein (BiP) also known as 78 kDa glucose-regulated protein (GRP-78) or heat shock 70 kDa protein 5 (HSPA5) is a protein that in humans is encoded by the HSPA5 gene. BiP is a HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum (ER) that binds newly synthesized proteins as they are translocated into the ER, and maintains them in a state competent for subsequent folding and oligomerization. BiP is also an essential component of the translocation machinery, as well as playing a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by the proteasome. Like many stress and heat shock proteins, BiP/GRP78 has potent immunological activity when released from the internal environment of the cell into the extracelluar space.specifically, it feeds anti-inflammatory and pro-resolutory signals into immune networks, thus helping to resolve inflammation.
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et al,Peroxiredoxin 4 deficiency induces accelerated ovarian aging through destroyed proteostasis in granulosa cells. In Biochim Biophys Acta Mol Basis Dis on 2024 Oct by Xiaofei Zou, Xiuru Liang et al..PMID:38971505
, (2024),
PMID:
38971505
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