产品详情
产品名称MLKL Rabbit mAb
克隆号SA40-04
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, IHC
种属反应性Human
免疫原描述recombinant protein
标记Unconjugated
别名9130019I15Rik antibody FLJ34389 antibody hMLKL antibody Mixed lineage kinase domain like antibody Mixed lineage kinase domain like protein antibody Mixed lineage kinase domain-like protein antibody Mlkl antibody MLKL_HUMAN antibody
数据库入口号Swiss-Prot#:Q8NB16
Uniprot
Q8NB16
计算分子量54 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-5,000
IHC: 1:50-1:200
Western blot analysis of MLKL on different cell lysates using anti-MLKL antibody at 1/1,000 dilution. Positive control: Lane 1: HT29 Lane 2: HUVEC Lane 3: Hela
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-MLKL antibody. Counter stained with hematoxylin.
MLKL (mixed lineage kinase domain-like) is a 471 amino acid protein that contains one protein kinase domain which is thought to be catalytically inactive. The gene encoding MLKL maps to chromosome 16 and is expressed as two isoforms which are produced by alternative splicing events. Chromosome 16, which is associated with a variety of genetic disorders, encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
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