产品详情
产品名称ATF2 Rabbit mAb
克隆号SZ17-01
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, ICC/IF, IHC, IP
种属反应性Human
免疫原描述recombinant protein
标记Unconjugated
别名Activating transcription factor 2 antibody Activating transcription factor 2 splice variant ATF2 var2 antibody ATF 2 antibody Atf-2 antibody Atf2 antibody ATF2 protein antibody ATF2_HUMAN antibody cAMP Response Element Binding Protein 2 antibody cAMP response element binding protein CRE BP1 antibody cAMP response element-binding protein CRE-BP1 antibody cAMP responsive element binding protein 2, formerly antibody cAMP-dependent transcription factor ATF-2 antibody cAMP-responsive element-binding protein 2 antibody CRE BP1 antibody CRE-BP antibody CREB 2 antibody CREB-2 antibody CREB2 antibody CREBP1 antibody Cyclic AMP dependent transcription factor ATF 2 antibody Cyclic AMP-dependent transcription factor ATF-2 antibody Cyclic AMP-responsive element-binding protein 2 antibody D130078H02Rik antibody D18875 antibody HB 16 antibody HB16 antibody Histone acetyltransferase ATF2 antibody MGC105211 antibody MGC105222 antibody MGC111558 antibody MGC142504 antibody mXBP antibody MXBP protein antibody Tg(Gzma-Klra1)7Wum antibody TREB 7 antibody TREB7 antibody
数据库入口号Swiss-Prot#:P15336
Uniprot
P15336
计算分子量54 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-ATF2 antibody. Counter stained with hematoxylin.
ICC staining ATF2 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining ATF2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining ATF2 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining ATF2 in PC-12 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Eukaryotic gene transcription is regulated by sequence-specific transcription factors which bind modular cis-acting promotor and enhancer elements. The ATF/CREB transcription factor family binds the palindromic cAMP response element (CRE) octanucleotide TGACGTCA. The ATF/CREB family includes CREB-1, CREB-2 (also designated ATF-4), ATF-1, ATF-2 and ATF-3. This family of proteins contain highly divergent N-terminal domains, but share a C-terminal leucine zipper for dimerization and DNA binding. ATF-2 forms homodimers and heterodimers with c-Jun to initiate CRE-dependent transcription. Phosphorylation of ATF-2 at Thr 69 and Thr 71 by stress-activated kinases is necessary for transcriptional activation. Myc also induces phosphorylation of ATF-2 at Thr 69 and Thr 71 to prolong the half-life of ATF-2. ATF-2 also functions as a histone acetyltransferase (HAT) by specifically acetylating histones H2B and H4 in vitro. The gene encoding human ATF-2 maps to chromosome 2q31.1.
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et al,A study on mechanism of SIRT3 inducing endocrine drug resistance in breast cancer via deacetylating YME1L1
, (2024),
PMID:
Yes
