产品详情
产品名称CDX2 Rabbit mAb
克隆号SY09-02
来源种属Recombinant Rabbit
克隆性Monoclonal antibody
纯化ProA affinity purified
应用WB, ICC/IF, IHC, FC
种属反应性Hu, Rt, Rabbit
免疫原描述recombinant protein
标记Unconjugated
别名Caudal type homeo box 2 antibody Caudal type homeo box transcription factor 2 antibody Caudal type homeobox 2 antibody Caudal type homeobox protein 2 antibody Caudal type homeobox transcription factor 2 antibody Caudal-type homeobox protein 2 antibody CDX 2 antibody CDX 3 antibody CDX-3 antibody Cdx2 antibody CDX2_HUMAN antibody CDX3 antibody Homeobox protein CDX 2 antibody Homeobox protein CDX-2 antibody
数据库入口号Swiss-Prot#:Q99626
Uniprot
Q99626
计算分子量34 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
ICC: 1:50-1:200
IF: 1:200-1:2,000
FC: 1:50-1:100
Western blot analysis of CDX2 on AGS cells lysates using anti-CDX2 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-CDX2 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded rat large intestine tissue using anti-CDX2 antibody. Counter stained with hematoxylin.
ICC staining CDX2 in LOVO cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining CDX2 in AGS cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of Hela cells with CDX2 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody
The members of the murine Cdx family (Cdx1, Cdx2, and Cdx4) are members of the caudal-type homeobox family of genes, which are homologues of the Drosophila 'caudal' gene required for anterior-posterior regional identity. The intestine-specific transcription factors Cdx1 and Cdx2 are candidate genes for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. The relative expression of Cdx1 to Cdx2 protein may be important in the anterior to posterior patterning of the intestinal epithelium and in defining patterns of proliferation and differentiation along the crypt-villus axis. Cdx1 and Cdx2 are expressed in the small intestine and colon of fetus and adult. A decrease in human Cdx1 and/or Cdx2 expression is associated with colorectal tumorigenesis. Both Cdx1 and Cdx2 genes must be expressed to reduce tumorigenic potential, to increase sensitivity to apoptosis, and to reduce cell migration, suggesting that the two genes control the normal phenotype by independent pathways.
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