产品详情
产品名称ABCG1 Rabbit mAb
克隆号SU03-26
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, ICC/IF, IHC
种属反应性Human;Rat
免疫原描述recombinant protein
标记Unconjugated
别名ABC transporter 8 antibody ABC8 antibody ABCG1 antibody ABCG1_HUMAN antibody ATP-binding cassette sub family G member 1 antibody ATP-binding cassette sub-family G member 1 antibody ATP-binding cassette transporter 8 antibody ATP-binding cassette transporter member 1 of subfamily G antibody ATP-binding cassette, sub family G WHITE member 1 antibody homolog of Drosophila white antibody MGC34313 antibody White protein homolog antibody White protein homolog ATP binding cassette transporter 8 antibody WHITE1 antibody WHT1 antibody
数据库入口号Swiss-Prot#:P45844
Uniprot
P45844
计算分子量110 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
ICC: 1:50-1:200
Western blot analysis of ABCG1 on THP-1 cell lysates using anti-ABCG1 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-ABCG1 antibody. Counter stained with hematoxylin.
ABCG1 (also designated ABC8 or human white gene), a member of the evolutionary conserved family of ATP-binding cassette (ABC) transporters, exhibits high homology with the Drosophila white gene. ABC transporters couple the energy of ATP hydrolysis to the translocation of various molecules across biological membranes. These proteins contain characteristic ATP-binding domains and transmembrane domains which form a channel-like structure for transport. ABCG1 functions to regulate cholesterol and phospholipid transport in macrophages. ABCG1 is highly expressed in several tissues, including brain, spleen, lung and placenta, and has been localized to the cell surface and intracellular compartments of cholesterol-laden macrophages.
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et al,Niacin-induced lysosomal free cholesterol efflux via LXRα-mediated signaling pathways in macrophages retards the progression of atherosclerosis
, (2025),
PMID:
Yes
