产品详情
产品名称CD44 Rabbit mAb
克隆号ST57-03
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, IHC, FC
种属反应性Human
免疫原描述recombinant protein
标记Unconjugated
别名LHR antibody BA-1 antibody CD 44 antibody CD44 antibody CD44 antigen antibody CD44 molecule (Indian blood group) antibody CD44 molecule antibody CD44_HUMAN antibody CDw44 antibody Cell surface glycoprotein CD44 antibody chondroitin sulfate proteoglycan 8 antibody CSPG8 antibody ECMR-III antibody Epican antibody Extracellular matrix receptor III antibody GP90 lymphocyte homing/adhesion receptor antibody HCELL antibody hematopoietic cell E- and L-selectin ligand antibody Heparan sulfate proteoglycan antibody Hermes antigen antibody homing function and Indian blood group system antibody HSA antibody HUTCH-I antibody HUTCH1 antibody Hyaluronate receptor antibody IN antibody MC56 antibody MDU2 antibody MDU3 antibody MGC10468 antibody MIC4 antibody MUTCH1 antibody PGP-1 antibody PGP-I antibody PGP1 antibody Phagocytic glycoprotein 1 antibody Phagocytic glycoprotein I antibody Soluble CD44 antibody
数据库入口号Swiss-Prot#:P16070
Uniprot
P16070
计算分子量82 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-5,000
IHC:1:50-1:200
FC: 1:50-1:100
Western blot analysis of CD44 on different lysates using anti-CD44 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela Lane 2: Jurkat
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD44 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-CD44 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-CD44 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-CD44 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-CD44 antibody. Counter stained with hematoxylin.
Flow cytometric analysis of Hela cells with CD44 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
Cell adhesion molecules (CAMs) are a family of closely related, cell surface glycoproteins that are involved in cell-cell interactions and are thought to play an important role in embryogenesis and development. HCAM, also known as CD44, LHR, MDU2, MDU3, MIC4, Pgp1, HCELL, MUTCH-I or ECMR-III, is a 742 amino acid single-pass type I membrane protein that is involved in hematopoiesis, lymphocyte activation and tumor metastasis. Functioning as a receptor for hyaluronic acid (HA) and interacting with ligands such as osteopontin (OPN), HCAM mediates both cell-cell and cell-matrix interactions, thereby playing an essential role in cell adhesion and cell migration. HCAM contains one Link domain and, due to alternative splicing events, is expressed as multiple isoforms, some of which are designated CD44R, CDw44, CD44S, CD44H (hematopoietic) and CD44E (epithelial). While most of the HCAM splice varients are expressed in tissues throughout the body, one specific isoform, namely CD44H, is expressed at high levels in cancer tissue, suggesting an important role for the CD44H splice varient in tumor progression.
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et al,Longitudinal plasma proteome profiling reveals the diversity of biomarkers for diagnosis and cetuximab therapy response of colorectal cancer. In Nat Commun on 2024 Feb 1 by Yan Li, Bing Wang,et al..PMID:38302471
, (2024),
PMID:
38302471
Yes
