产品详情
产品名称PI3-kinase p110 subunit beta Rabbit mAb
克隆号SC0580
来源种属Recombinant Rabbit
克隆性Monoclonal antibody
纯化ProA affinity purified
应用WB, IP, FC, IHC
种属反应性Human
免疫原描述recombinant protein
标记Unconjugated
别名5-bisphosphate 3-kinase 110 kDa catalytic subunit beta antibody 5-bisphosphate 3-kinase catalytic subunit beta isoform antibody DKFZp779K1237 antibody MGC133043 antibody OTTHUMP00000216901 antibody OTTHUMP00000216904 antibody p110 BETA antibody p110Beta antibody Phosphatidylinositol 3 kinase catalytic beta polypeptide antibody Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit beta antibody Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit beta isoform antibody Phosphatidylinositol-4 antibody Phosphoinositide 3 kinase catalytic beta polypeptide antibody PI3 kinase p110 subunit beta antibody PI3-kinase subunit beta antibody PI3K antibody PI3K beta antibody PI3K-beta antibody PI3Kbeta antibody PI3KCB antibody PIK3C1 antibody Pik3cb antibody PK3CB_HUMAN antibody PtdIns 3 kinase p110 antibody PtdIns-3-kinase subunit beta antibody PtdIns-3-kinase subunit p110-beta antibody
数据库入口号Swiss-Prot#:P42338
Uniprot
P42338
计算分子量123 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000
IHC: 1:50-1:100
FC: 1:50-1:100
Western blot analysis of PI3-kinase p110 subunit beta on Hela cell lysates using anti-PI3-kinase p110 subunit beta antibody at 1/1,000 dilution.
Flow cytometric analysis of Hela cells with PI3-kinase p110 subunit beta antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG wa secondary
Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85α and p85β), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110α and p110β interact with p85α, and p110α has also been shown to interact with p85β in vitro. p110 expression is restricted to white blood cells. It has been shown to bind p85α and β, but it apparently does not phosphorylate these subunits. p110δ seems to have the capacity to autophosphorylate. p110γ does not interact with the p85 subunits. It has been shown to be activated by α and β γ heterotrimeric G proteins.
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