产品详情
产品名称NLRP3 Rabbit mAb
克隆号SC06-23
来源种属Recombinant Rabbit
克隆性Monoclonal antibody
纯化ProA affinity purified
应用WB, ICC/IF, IHC, IP, FC
种属反应性Human;Mouse;Rat
免疫原描述recombinant protein
标记Unconjugated
别名AGTAVPRL antibody
AII/AVP antibody
Angiotensin/vasopressin receptor AII/AVP like antibody
Angiotensin/vasopressin receptor AII/AVP-like antibody
C1orf7 antibody
Caterpiller protein 1.1 antibody
CIAS 1 antibody
CIAS1 antibody
CLR1.1 antibody
Cold autoinflammatory syndrome 1 antibody
Cold autoinflammatory syndrome 1 protein antibody
Cryopyrin antibody
Familial cold autoinflammatory syndrome antibody
FCAS antibody
FCU antibody
LRR and PYD domains-containing protein 3 antibody
Muckle-Wells syndrome antibody
MWS antibody
NACHT antibody
NACHT LRR and PYD containing protein 3 antibody
NALP 3 antibody
NALP3 antibody
NALP3_HUMAN antibody
NLRP3 antibody
PYPAF 1 antibody
PYPAF1 antibody
PYRIN containing APAF1 like protein 1 antibody
PYRIN-containing APAF1-like protein 1 antibody
数据库入口号Swiss-Prot#:Q96P20
Uniprot
Q96P20
计算分子量118/85 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:100-1:500
FC: 1:50-1:100
Immunohistochemical analysis of paraffin-embedded mouse bladder tissue using anti- NLRP3 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti- NLRP3 antibody. Counter stained with hematoxylin.
ICC staining NLRP3 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining NLRP3 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining NLRP3 in PMVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of Jurkat cells with NLRP3 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
Western blot analysis of lysates from 293,MCF7 and U-87 MG cells using NLRP3 Rabbit mAb.
Cryopyrin interacts selectively with apoptosis-associated specklike protein containing a CARD domain (ASC). This complex may function as an upstream activator of NFkB signaling and caspase-1 activation. The complex also inhibits TNFa induced activation and nuclear translocation of RelA/NFkB p65. Mutations in Cryopyrin and Pyrin proteins are responsible for several autoinflammatory disorders in humans, including familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and chronic infantile neurologic cutaneous and articular syndrome (CINCA).
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et al,Monotropein alleviates secondary liver injury in chronic colitis by regulating TLR4/NF-kB signaling and NLRP3 inflammasome . In Eur J Pharmacol on 2020 Sep 15 by Yonger Chen , Yingyu Lu, et al..PMID:32710952, , (2020)
, (2020),
PMID:
32710952
et al,Ginsenoside Rk3 alleviated DSS-induced ulcerative colitis by protecting colon barrier and inhibiting NLRP3 inflammasome pathway. In Int Immunopharmacol on 2020 Aug by Mi Tian, Pei Ma, et al..PMID: 32521491
, (2020),
PMID:
32521491
et al,Interventional Efects of the Topical of "Sanse Powder" Essential Oils Nanoemulsion on Knee Osteoarthritis in Rats by Targeting the ERS/TXNIP/NLRP3 Signaling Axis.In Front Pharmacol on 2021 Sep 2 by Zixiu Liu, Taiyang Liao, et al..
, (2021),
PMID:
34539417
et al,Interventional Efects of the Topical of "Sanse Powder" Essential Oils Nanoemulsion on Knee Osteoarthritis in Rats by Targeting the ERS/TXNIP/NLRP3 Signaling Axis.In Front Pharmacol on 2021 Sep 2 by Zixiu Liu, Taiyang Liao, et al..PMID: 34539417
, (2021),
PMID:
34539417
et al,Neuro-immune interaction in CNS injury and diseaseInImmunol RevOn2023 Mar 1byB Li, G Ning et al..PMID:35067941
, (2023),
PMID:
35067941
et al,Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury
, (2022),
PMID:
36238284
et al,Vitexin alleviates MNNG-induced chronic atrophic gastritis via inhibiting NLRP3 inflammasome.
, (2025),
PMID:
39716512
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