产品详情
产品名称IKB beta Rabbit mAb
克隆号SN0648
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, ICC, IHC, IP
种属反应性Human
免疫原描述recombinant protein
标记Unconjugated
别名I kappa B beta antibody I-kappa-B-beta antibody IkappaBbeta antibody IKB beta antibody IkB-B antibody IkB-beta antibody IKBB antibody IKBB_HUMAN antibody IkBbeta antibody NF kappa BIB antibody NF-kappa-B inhibitor beta antibody NF-kappa-BIB antibody Nfkbib antibody Thyroid receptor interacting protein 9 antibody Thyroid receptor-interacting protein 9 antibody TR interacting protein 9 antibody TR-interacting protein 9 antibody TRIP-9 antibody TRIP9 antibody
数据库入口号Swiss-Prot#:Q15653
Uniprot
Q15653
计算分子量48 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200
Western blot analysis of IKB beta on different lysates using anti-IKB beta antibody at 1/1,000 dilution. Positive control: Lane 1: Jurkat Lane 2: Hela Lane 3: THP-1
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-IKB beta antibody. Counter stained with hematoxylin.
ICC staining IKB beta in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining IKB beta in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
On the basis of both functional and structural considerations, members of the IkB family of proteins can be divided into four groups. The first of these groups, IkB-α, includes the avian protein pp40 and the mammalian MAD-3, both of which inhibit binding of p50-p65 NFkB complex or Rel protein to their cognate binding sites but do not inhibit the binding of p50 homodimer to kB sites, suggesting that the IkB-α family binds to the p65 subunit of p50-p65 heterocomplex through ankyrin repeats. The second member of the IkB family is represented by a protein designated IkB-β. The third group of IkB proteins is represented by IkB-ε, which is identical in sequence with the C-terminal domain of the p110 precursor of NFkB p50 and is expressed predominantly in lymphoid cells. An additional IkB family member, IkB-��, has several phosphorylated forms and is primarily found complexed with Rel A and/or c-Rel.
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