产品详情
产品名称Nestin Rabbit mAb
克隆号SN06-27
来源种属Recombinant Rabbit
克隆性Monoclonal antibody
纯化ProA affinity purified
应用ICC/IF, IHC, WB
种属反应性Human
免疫原描述recombinant protein
标记Unconjugated
别名ESTM 46 antibody FLJ 21841 antibody FLJ21841 antibody Intermediate filament protein antibody Nbla00170 antibody nes antibody NEST_HUMAN antibody Nestin antibody
数据库入口号Swiss-Prot#:P48681
Uniprot
P48681
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
IHC: 1:50-1:200
ICC: 1:50-1:200
WB: 1:1,000
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Nestin antibody. Counter stained with hematoxylin.
Nestin is a major intermediate filament (IF) protein of embryonic central nervous system progenitor cells. It is also a component of the dynamic IF network during muscle development, where it polymerizes with Desmin and Vimentin. Nestin co-assembles with Vimentin or a-internexin and forms heterodimer coiled-coil molecules which then further assemble into 10 nml IFs. Deletion of the IF consensus rod domain in nestin alters nestin localization in CNS precursor cells and radial glial cells in vivo. Nestin is a marker for neuroepithelial stem cells, glioma cells and tumor endothelial cells during rapid growth. During axon elongation of differen-tiation neurons, nestin localizes to the growth cones and may play a role in growth cone guidance. In the rat adrenal gland, nestin is expressed by the zona fasciculata and the zona reticularis. Nestin is also expressed by dermatomal cells and by myoblasts during the earliest stages of myogenesis.
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