产品详情
产品名称Cytokeratin 6 Rabbit mAb
克隆号SN71-07
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, ICC/IF, IHC
种属反应性Human
免疫原描述recombinant protein
标记Unconjugated
别名CK 6A antibody CK 6B antibody CK 6C antibody CK 6D antibody CK 6E antibody CK-6C antibody CK-6E antibody Cytokeratin 6a antibody Cytokeratin 6B antibody Cytokeratin 6C antibody Cytokeratin 6D antibody Cytokeratin 6E antibody Cytokeratin-6C antibody Cytokeratin-6E antibody K2C6C_HUMAN antibody K6a keratin antibody K6b keratin antibody K6C antibody K6c keratin antibody K6d keratin antibody K6e keratin antibody Keratin antibody Keratin K6h antibody Keratin type II cytoskeletal 6A antibody Keratin type II cytoskeletal 6B antibody Keratin type II cytoskeletal 6C antibody Keratin type II cytoskeletal 6D antibody Keratin type II cytoskeletal 6E antibody Keratin-6C antibody KRT6A antibody KRT6B antibody KRT6C antibody KRT6D antibody KRT6E antibody type II cytoskeletal 6C antibody Type-II keratin Kb12 antibody
数据库入口号Swiss-Prot#:P02538
Uniprot
P02538
计算分子量60 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
ICC: 1:100-1:500
Western blot analysis of Cytokeratin 6 on human skin lysates using anti-Cytokeratin 6 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Cytokeratin 6 antibody. Counter stained with hematoxylin.
ICC staining Cytokeratin 6 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins, which are useful markers of tissue differentiation, also aid in the characterization of malignant tumors. IL-1 and TNFα induce transcription of cytokeratin 6 in epidermal keratinocytes via the C/EBP β transcription factor. In humans, multiple isoforms of cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies.
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