产品详情
产品名称SHP2 Rabbit mAb
克隆号SN07-32
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, ICC/IF, IHC, IP
种属反应性Human
免疫原描述recombinant protein
标记Unconjugated
别名BPTP3 antibody CFC antibody JMML antibody METCDS antibody MGC14433 antibody NS1 antibody OTTHUMP00000166107 antibody OTTHUMP00000166108 antibody Protein tyrosine phosphatase 2 antibody Protein tyrosine phosphatase 2C antibody Protein tyrosine phosphatase non receptor type 11 antibody Protein-tyrosine phosphatase 1D antibody Protein-tyrosine phosphatase 2C antibody PTN11_HUMAN antibody PTP-1D antibody PTP-2C antibody PTP1D antibody PTP2C antibody PTPN11 antibody SAP2 antibody SH-PTP2 antibody SH-PTP3 antibody SH2 domain containing protein tyrosine phosphatase 2 antibody SHP 2 antibody SHP-2 antibody Shp2 antibody SHPTP2 antibody SHPTP3 antibody Syp antibody Tyrosine-protein phosphatase non-receptor type 11 antibody
数据库入口号Swiss-Prot#:Q06124
Uniprot
Q06124
计算分子量70 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
ICC: 1:50-1:200
Western blot analysis of SHP2 on different lysates using anti-SHP2 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela Lane 2: 293
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-SHP2 antibody. Counter stained with hematoxylin.
ICC staining SHP2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining SHP2 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining SHP2 in NIH/3T3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. SH2 domains generally mediate the association of regulatory molecules with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby controlling the initial interaction of receptors with these substrates. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified. Strong sequence similarity between SH-PTP2 and the Drosophila gene corkscrew (CSW) and their similar patterns of expression suggest that SH-PTP2 is the human corkscrew homolog.
如果您使用该产品49096发表了文章，请通知我们，让我们可以引用您的文献。
et al,Grass carp (Ctenopharyngodon idellus) SHP2 suppresses IFN I expression via decreasing the phosphorylation of GSK3 beta in a non-contact manner
, (2021),
PMID:
34265416
Yes
