免费电话:400-9961-933
邮箱:info@sabbiotech.com
欢迎光临本站
川博智能体 English
位置: 首页 > 重组兔单抗 > Insulin Receptor Beta Rabbit mAb

Insulin Receptor Beta Rabbit mAb#49107

是否有货: Yes
产品详情

产品名称Insulin Receptor Beta Rabbit mAb

克隆号SN20-13

来源种属Recombinant Rabbit

克隆性Monoclonal

纯化ProA affinity purified

应用WB, ICC/IF, IHC

种属反应性Human;Mouse;Rat

免疫原描述Synthetic peptide within human Insulin receptor aa 930-970.

标记Unconjugated

别名CD220 antibody
HHF5 antibody
HIR A antibody
INSR antibody
Insulin receptor antibody
Insulin receptor subunit Beta antibody
IR antibody

数据库入口号Swiss-Prot#:P06213

Uniprot P06213

Gene ID 3643;

计算分子量156 kDa

配方1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

保存Store at -20˚C

应用详情

WB: 1:1,000-1:2,000
IHC: 1:1,000
ICC: 1:100-1:500

Western blot analysis of Insulin Receptor on different lysates using anti-Insulin Receptor antibody at 1/1,000 dilution. Positive control:
Lane 1: 293
Lane 2: MCF-7
Lane 3: Hela
ICC staining Insulin Receptor in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining Insulin Receptor in LO2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining Insulin Receptor in RH-35 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining Insulin Receptor in PANC-1 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular β subunit and an extracellular α subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. The human insulin receptor gene maps to chromosome 19p13.3-p13.2 and encodes a 1382 amino acid protein that cleaves to form α and β subunits. Type 1 diabetes is an auto-immune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells. Type 2 diabetes is a condition where cells become resistant to insulin action.

如果您使用该产品49107发表了文章,请通知我们,让我们可以引用您的文献。

et al,Neuromechanical Dimorphism of Hypoglycemic Effect of ElectroacupunctureInNeuroendocrinologyOn2023byYun Liu?1,?Tiancheng Xu et al..PMID:?36623492 , (2023),
PMID: 36623492

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk
;

联系我们

Location :

南京市高新开发区星火路10号人才大厦C座

Phone :

400-9961-933
025-58868422

Email Address

info@sabbiotech.com