产品详情
产品名称IRF5 Rabbit mAb
克隆号SN201-05
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, IHC, FC
种属反应性Human
免疫原描述recombinant protein
标记Unconjugated
别名Interferon regulatory factor 5 antibody Interferon regulatory factor 5 bone marrow variant antibody IRF 5 antibody IRF-5 antibody Irf5 antibody IRF5_HUMAN antibody SLEB10 antibody
数据库入口号Swiss-Prot#:Q13568
Uniprot
Q13568
计算分子量56 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-5,000
IHC: 1:50-1:200
FC: 1:50-1:100
Western blot analysis of IRF5 on THP-1 cells lysates using anti-IRF5 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-IRF5 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-IRF5 antibody. Counter stained with hematoxylin.
Flow cytometric analysis of K562 cells with IRF5 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody
Interferon regulatory factor 5 (IRF-5), belongs to the IRF family of DNA-binding factors, which includes IRF-1, IRF-2, IRF-3, IRF-4, IRF-6, IRF-7, ISGF-3γ p48 and IFN consensus sequence-binding protein (ICSBP). The IRF family regulate both interferon and interferon-inducible genes. IRF-5, like IRF-3 and IRF-7, is a direct transducer of virus-mediated signaling and plays a role in the expression of multiple cytokines/chemokines. Although IRF-5 is a direct target of p53, its cell cycle regulatory and proapoptotic effects are p53 independent.
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