产品详情
产品名称RelB Rabbit mAb
克隆号SD07-39
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, ICC/IF, IHC, IP
种属反应性Human
免疫原描述recombinant protein
标记Unconjugated
别名I REL antibody I-Rel antibody IREL antibody Nuclear factor of kappa light polypeptide gene enhancer in B cells 3 antibody relB antibody RELB_HUMAN antibody Reticuloendotheliosis viral oncogene homolog B antibody Transcription factor Rel B antibody Transcription factor RelB antibody v rel avian reticuloendotheliosis viral oncogene homolog B antibody v rel reticuloendotheliosis viral oncogene homolog B antibody
数据库入口号Swiss-Prot#:Q01201
Uniprot
Q01201
计算分子量62 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-RelB antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-RelB antibody. Counter stained with hematoxylin.
ICC staining RelB in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining RelB in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining RelB in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
The NFκB transcription factor was originally identified as a protein complex consisting of a DNA binding subunit and an associated protein. The DNA binding subunit is functionally related to c-Rel p75 and Rel B p68. The p50 subunit was initially believed to be a functionally unique protein derived from the amino terminus of a precursor designated p105. A second protein designated p52 (previously referred to as p49) has been identified that can act as an alternative NFκB subunit. Rel B does not bind with high affinity to NFkB sites, but heterodimers between Rel B and p50 bind with an affinity comparable to that of p50 NFκB homodimers. However, Rel B/p50 heterodimers, in contrast to NFκB heterodimers, transactivates transcription of promotors containing κB binding sites.
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