产品详情
产品名称MHC Class II Rabbit mAb
克隆号JA10-94
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, IP, ICC/IF, IHC
种属反应性Human
免疫原描述recombinant protein
标记Unconjugated
别名D6S221E antibody
DMA antibody
DMB antibody
DP beta 1 antibody
DP beta 1 chain antibody
DP(W4) beta chain antibody
DPB 1 antibody
DPB1 antibody
DPB1_HUMAN antibody
DRB antibody
H2Ea antibody
HLA class II histocompatibility antigen antibody
HLA class II histocompatibility antigen DM beta chain antibody
HLA class II histocompatibility antigen, DP beta 1 chain antibody
HLA class II histocompatibility antigen, DP(W4) beta chain antibody
HLA DMB antibody
HLA DP1A antibody
HLA DPB1 antibody
HLA SB alpha chain antibody
HLA-A antibody
HLA-A histocompatibility type antibody
HLA-DP antibody
HLA-DP histocompatibility type, beta-1 subunit antibody
HLA-DP1B antibody
HLA-DPB antibody
HLA-DPB1 antibody
HLADM antibody
HLADP1B antibody
HLASB antibody
HLASB histocompatibility type antibody
Human MHC class II HLA SB alpha antibody
LA class II histocompatibility antigen DP alpha 1 chain antibody
Major histocompatibility complex class II antibody
Major histocompatibility complex class II DP alpha 1 antibody
Major histocompatibility complex class II DP beta 1 antibody
Major histocompatibility complex, class I, A antibody
MHC class II antigen DMB antibody
MHC class II antigen DPB1 antibody
MHC class II DP3 alpha antibody
MHC class II DPA1 antibody
MHC class II HLA-DP-beta-1 antibody
MHC DPB1 antibody
MHC HLA DPB1 antibody
PLT1 antibody
Primed lymphocyte test 1 antibody
RING6 antibody
RING7 antibody
数据库入口号Swiss-Prot#:P04440
Uniprot
P04440
计算分子量29 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:100
IP: 1:10-1:50
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti- MHC Class II antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti- MHC Class II antibody. Counter stained with hematoxylin.
Major histocompatibility complex (MHC) molecules, also designated human leukocyte antigen (HLA) molecules, are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an α or heavy chain and β-2-Microglobulin, a non-covalently associated protein. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically eight to ten residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an α and β chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumu-lating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.
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PMID:
33372534
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