产品详情
产品名称NFkB p100 Rabbit mAb
克隆号JM82-03
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, ICC/IF, IHC, IP
种属反应性Human;Mouse;Rat
免疫原描述Recombinant protein
标记Unconjugated
别名CVID10 antibody
DNA binding factor KBF2 antibody
H2TF1 antibody
Lymphocyte translocation chromosome 10 protein antibody
LYT 10 antibody
NF kB2 antibody
NFKB p52/p100 subunit antibody
Nuclear factor Kappa B subunit 2 antibody
Nuclear factor of kappa light polypeptide gene enhancer in B cells 2 (p49/p100) antibody
Nuclear factor of kappa light polypeptide gene enhancer in B cells 2 antibody
Oncogene Lyt 10 antibody
p100 antibody
Transcription factor NFKB2 antibody
数据库入口号Swiss-Prot#:Q00653
Uniprot
Q00653
计算分子量100 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:2,000
IHC: 1:50-1:200
ICC: 1:50-1:200
Western blot analysis of NFkB p100 on Hela (1) and MCF-7 (2) cell using anti-NFkB p100 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-NFkB p100 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-NFkB p100 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-NFkB p100 antibody. Counter stained with hematoxylin.
ICC staining NFkB p100 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining NFkB p100 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65.
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et al,The role of FTO in m6A RNA methylation and immune regulation in Staphylococcus aureus infection-related osteomyelitis.
, (2025),
PMID:
39980685
Yes
