产品详情
产品名称Ferritin Heavy Chain Rabbit mAb
克隆号JM22-36
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, IHC, ICC
种属反应性Human;Mouse;Rat
免疫原描述Recombinant protein
标记Unconjugated
别名Apoferritin antibody
Cell proliferation inducing gene 15 protein antibody
Cell proliferation-inducing gene 15 protein antibody
F HC antibody
Ferritin H subunit antibody
Ferritin heavy chain antibody
Ferritin heavy polypeptide 1 antibody
FHC antibody
FRIH antibody
FRIH_HUMAN antibody
FTH 1 antibody
FTH antibody
FTH1 antibody
FTH1 protein antibody
FTHL 6 antibody
FTHL6 antibody
Iron overload autosomal dominant antibody
MGC104426 antibody
N-terminally processed antibody
OK/SW-cl.84 antibody
PIG 15 antibody
PIG15 antibody
Placenta immunoregulatory factor antibody
PLIF antibody
Proliferation inducing gene 15 protein antibody
Proliferation inducing protein 15 antibody
数据库入口号Swiss-Prot#:P02794
Uniprot
P02794
计算分子量21 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:1000
IHC: 1:50-1:200
ICC: 1:50-1:200
Mammalian ferritins consist of 24 subunits made up of two types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of FeII, whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of FeIII. The most prominent role of mamma-lian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed; and oxidative stress, an important factor in the development of aging-related cataracts.
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et al,Iron promotes ovarian cancer malignancy and advances platinum resistance by enhancing DNA repair via FTH1/FTL/POLQ/RAD51 axis. In Cell Death Dis on 2024 May 13 by Qingyu Zhang, Caiyun Chen,et al..PMID:38740757
, (2024),
PMID:
38740757
Yes
