产品详情
产品名称PDX1 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, IHC, ICC/IF
种属反应性Human
免疫原描述Recombinant protein
标记Unconjugated
别名Glucose sensitive factor antibody
Glucose-sensitive factor antibody
GSF antibody
IDX 1 antibody
IDX-1 antibody
IDX1 antibody
Insulin promoter factor 1 antibody
Insulin promoter factor 1 homeodomain transcription factor antibody
Insulin upstream factor 1 antibody
IPF 1 antibody
IPF-1 antibody
IPF1 antibody
Islet/duodenum homeobox 1 antibody
Islet/duodenum homeobox-1 antibody
IUF 1 antibody
IUF-1 antibody
IUF1 antibody
MODY4 antibody
Pancreas/duodenum homeobox 1 antibody
Pancreas/duodenum homeobox protein 1 antibody
pancreatic and duodenal homeobox P antibody
PDX 1 antibody
PDX-1 antibody
PDX1 antibody
PDX1_HUMAN antibody
Somatostatin transactivating factor 1 antibody
Somatostatin-transactivating factor 1 antibody
STF 1 antibody
STF-1 antibody
STF1 antibody
数据库入口号Swiss-Prot#:P52945
Uniprot
P52945
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
IHC: 1:50-1:200
ICC/IF: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-PDX1 antibody. Counter stained with hematoxylin.
IF analysis of paraffin-embedded human pancreas tissue using anti-PDX1 antibody (green��. The nuclear counter stain is DAPI (blue).
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.
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et al,Therapeutic effects and mechanisms of Xinmaitong formula for type 2 diabetes mellitus via GLP-1R signaling
, (2025),
PMID:
40271065
Yes
