产品详情
产品名称SHP2 Rabbit mAb
克隆号S08-3G2
来源种属Recombinant Rabbit
克隆性Monoclonal antibody
亚型Rabbit IgG
纯化Affinity Purified
应用WB IHC
种属反应性Human
免疫原描述A synthetic peptide of human SHP2
标记Unconjugated
别名CFC, NS1, SHP2, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP
数据库入口号Swiss-Prot:Q06124
GeneID:5781
Uniprot
Q06124
Gene ID
5781
计算分子量Calculated MW: 68 kDa; Observed MW: 68 kDa
配方50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
保存Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
应用详情
WB: 1/2000; IHC: 1/20;
Western blot detection of SHP2 in Hela,293 cell lysates using SHP2 Rabbit mAb(1:1000 diluted).Predicted band size:68kDa.Observed band size:68kDa.
Immunohistochemistry of SHP2 in paraffin-embedded Human breast cancer tissue using SHP2 Rabbit mAb at dilution 1/50
Swiss-Prot Acc.Q06124.Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573).
Positively regulates MAPK signal transduction pathway (PubMed:28074573).
Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573).
Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669).
Dephosphorylates CDC73 (PubMed:26742426).
Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity).
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et al,Grass carp (Ctenopharyngodon idellus) SHP2 suppresses IFN I expression via decreasing the phosphorylation of GSK3 beta in a non-contact manner
, (2021),
PMID:
34265416
Yes
