产品详情
产品名称TBK1 Rabbit mAb
来源种属Recombinant Rabbit
克隆性Monoclonal antibody
亚型Rabbit IgG
纯化Affinity-chromatography
应用WB;IHC;IF
种属反应性Human;Mouse;Rat
免疫原类型Peptide
免疫原描述A synthetic peptide of human TBK1
标记Unconjugated
别名NAK; T2K; NF-kappa-B-activating kinase; TANK-binding kinase 1; Serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1;
数据库入口号Swiss-Prot:Q9UHD2
GeneID:29110
Uniprot
Q9UHD2
Gene ID
29110
计算分子量Calculated MW: 84 kDa; Observed MW: 84 kDa
配方Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
保存Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
应用详情
WB 1:1000-1:2000;
IHC 1:100-1:200;
IF 1:50-1:200
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
Immunohistochemical analysis of paraffin-embedded Rat liver, using the Antibody at 1:100 dilution.
Immunohistochemical analysis of paraffin-embedded human testis, using TBK1 Rabbit mAb.
Immunohistochemical analysis of paraffin-embedded Mouse skin, using the Antibody at 1:100 dilution.
Swiss-Prot Acc.Q9UHD2. Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800).Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631).Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus
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et al,Therapeutic Effect of Brucea Javanica Oil Emulsion in Mice with Irinotecan-Induced Delayed Diarrhea
, (2025),
PMID:
40584920
Yes
