产品详情
产品名称ABCG1 Rabbit mAb
克隆号S06-5B9
来源种属Recombinant Rabbit
克隆性Monoclonal antibody
亚型Rabbit IgG
纯化Affinity Purified
应用WB
种属反应性Human;Mouse;Rat
免疫原描述A synthetic peptide of human ABCG1
标记Unconjugated
别名ATP-binding cassette transporter 8; White protein homolog; ABC8; WHT1;ABCG1; ABC transporter 8; WHITE1;
数据库入口号Swiss-Prot:P45844
GeneID:9619
Uniprot
P45844
Gene ID
9619
计算分子量Calculated MW: 76 kDa; Observed MW: 100 kDa
配方50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
保存Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
应用详情
WB: 1/2000
Western blot detection of ABCG1 in Hela cell lysates using ABCG1 Rabbit mAb(1:1000 diluted).Predicted band size:76kDa.Observed band size:100kDa.
Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP (PubMed:17408620, PubMed:24576892).
The lipid efflux is ALB-dependent (PubMed:16702602).
Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (PubMed:17408620).
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et al,Niacin-induced lysosomal free cholesterol efflux via LXRα-mediated signaling pathways in macrophages retards the progression of atherosclerosis
, (2025),
PMID:
Yes
