产品详情
产品名称Myelin Basic Protein Rabbit mAb
克隆号S03-8D1
来源种属Recombinant Rabbit
克隆性Monoclonal antibody
亚型Rabbit IgG
纯化Affinity Purified
应用WB
种属反应性Human;Mouse;Rat
免疫原描述Recombinant protein of human Myelin Basic Protein
标记Unconjugated
别名Myelin membrane encephalitogenic protein;Myelin A1 protein
数据库入口号Swiss-Prot:P02686
GeneID:4155
Uniprot
P02686
Gene ID
4155
计算分子量Calculated MW: 33 kDa; Observed MW: 18 kDa
配方50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
保存Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
应用详情
WB: 1/1000-1/5000
Western blot detection of Myelin Basic Protein in Hela,CHO-K1,C6 cell lysates using Myelin Basic Protein Rabbit mAb(1:500 diluted).Predicted band size:33kDa.Observed band size:18kDa.
Swiss-Prot Acc.P02686.The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
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et al,Implantation with SHED sheet induced with homogenate protein of spinal cord promotes functional recovery from spinal cord injury in ratsInFront Bioeng BiotechnolOn2023 Mar 14bySisi Mi 1, Xue Wang et al..PMID: 36998812
, (2023),
PMID:
36998812
Yes
