产品详情
产品名称TRAF6 Rabbit mAb
克隆号S09-3F4
来源种属Recombinant Rabbit
克隆性Monoclonal antibody
亚型Rabbit IgG
纯化Affinity Purified
应用WB
种属反应性Human;Mouse;Rat
免疫原描述A synthetic peptide of human TRAF6
标记Unconjugated
别名RNF85; MGC:3310
数据库入口号Swiss-Prot:Q9Y4K3
GeneID:7189
Uniprot
Q9Y4K3
Gene ID
7189
计算分子量Calculated MW: 60 kDa; Observed MW: 60 kDa
配方50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
保存Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
应用详情
WB: 1/1000-1/5000;
Western blot detection of TRAF6 in 293 cell lysates using TRAF6 Rabbit mAb(1:1000 diluted).Predicted band size:60KDa.Observed band size:60KDa.
Swiss-Prot Acc.Q9Y4K3.E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.
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, (2025),
PMID:
39736347
Yes
