产品详情
产品名称TNNI3 Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IF
种属反应性Mouse;Rat
免疫原描述Recombinant fusion protein of human TNNI3 (NP_000354.4).
标记Unconjugated
别名TNNI3;CMD1FF;CMD2A;CMH7;RCM1;TNNC1;cTnI;troponin I3
数据库入口号Swiss Prot:P19429
GeneID:7137
Uniprot
P19429
计算分子量24kDa
实际分子量30kDa
配方Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using TNNI3 at 1:1000 dilution.
Immunofluorescence analysis of mouse heart cells using TNNI3 at dilution of 1:100. Blue: DAPI for nuclear staining.
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
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