产品详情
产品名称NFKB1 Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB;IHC;IF;IP
种属反应性Human
免疫原描述Recombinant fusion protein of human NFKB1 (NP_001158884.1).
标记Unconjugated
别名NFKB1;CVID12;EBP-1;KBF1;NF-kB1;NF-kappa-B;NF-kappaB;NFKB-p105;NFKB-p50;NFkappaB;p105;p50
数据库入口号Swiss Prot:P19838
GeneID:4790
Uniprot
P19838
计算分子量85kDa/105kDa
实际分子量120kDa
配方Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:50-1:500; IP 1:25-100
Western blot analysis of extracts of Raji and MCF7 cells, using NFKB1 Rabbit Polyclonal Antibody.
Western blot analysis of extracts of Hela and 231 cells, using NFKB1 Rabbit Polyclonal Antibody.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFkB-p105(Ab-932) Antibody(left) or the same antibody preincubated with blocking peptide(right).
Immunohistochemistry of paraffin-embedded human tonsil using NFKB1 at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded Human ovarian cancer using NFKB1 Antibody
Immunofluorescence analysis of MCF7 cells using NFKB1 .
Immunofluorescence analysis of A-549 cells using NFKB1 Rabbit pAb at dilution of 1:50 (40x lens).
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.
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et al,The role of FTO in m6A RNA methylation and immune regulation in Staphylococcus aureus infection-related osteomyelitis.
, (2025),
PMID:
39980685
Yes
