产品详情
产品名称E-Cadherin Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
免疫原描述A synthetic peptide of human E-Cadherin (NP_004351.1).
标记Unconjugated
别名Arc-1;CD324;CDHE;ECAD;LCAM;UVO;CDH1;E-Cadherin
数据库入口号Uniprot:P12830
GeneID:999
Uniprot
P12830
Gene ID
999
计算分子量90kDa/97kDa
实际分子量80KDa
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:1000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using E-Cadherin antibody.
Immunohistochemistry of paraffin-embedded Rat kidney using E-Cadherin antibody.
Immunofluorescence analysis of A431 cells using E-Cadherin Rabbit pAb.
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
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et al,Overexpression of Epithelial Splicing Regulatory Protein 1 in Metastatic Lesions of Serous Ovarian Carcinoma Correlates with Poor Patient Prognosis. In Cancer Biother Radiopharm on 2021 Sep 8 by Xinxin Lu, Runzhou Li, et al..PMID:34495766
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34495766
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Yes
