产品详情
产品名称CASC5 Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Rat
免疫原描述Recombinant fusion protein of human CASC5 (NP_733468.3).
标记Unconjugated
别名AF15Q14;CASC5;CT29;D40;MCPH4;PPP1R55;Spc7;hKNL-1;hSpc105;KNL1
数据库入口号Swiss Prot:Q8NG31
GeneID:57082
Uniprot
Q8NG31
计算分子量195kDa/205kDa/262kDa/265kDa
实际分子量300kDa
配方Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:100
IF 1:50 - 1:100
Western blot analysis of extracts of various cell lines, using CASC5 at 1:3000 dilution.
Immunohistochemistry of paraffin-embedded rat testis using CASC5 at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human colon using CASC5 at dilution of 1:100 (40x lens).
The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.
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et al,Synthesis of an RBM39 Degrader That Downregulates CEP192 and Induces Disorganized Spindle Structures.
, (2025),
PMID:
40107850
Yes
