产品详情
产品名称CD68 Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
免疫原描述Recombinant fusion protein of human CD68 (NP_001242.2).
标记Unconjugated
别名CD68;GP110;LAMP4;SCARD1
数据库入口号Swiss Prot:P34810
GeneID:968
Uniprot
P34810
计算分子量31kDa/34kDa/37kDa
实际分子量80-110KDa
配方Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Immunohistochemistry of paraffin-embedded Human oophoroma using CD68 at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Mouse spleen using CD68 at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using CD68 Polyclonal at 1:1000 dilution.
Western blot analysis of extracts of Rat thymus, using CD68 Polyclonal at 1:1000 dilution.
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
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et al,Engineering extracellular vesicles derived from endothelial cells sheared by laminar flow for anti-atherosclerotic therapy through reprogramming macrophage.
, (2025),
PMID:
39270628
Yes
