产品详情
产品名称TYR Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB
种属反应性Human;Rat
免疫原描述Recombinant fusion protein of human TYR (NP_000363.1).
标记Unconjugated
别名TYR;ATN;CMM8;OCA1;OCA1A;OCAIA;SHEP3
数据库入口号Uniprot:P14679
GeneID:7299
Uniprot
P14679
Gene ID
7299
计算分子量42kDa/60kDa
实际分子量80kDa
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
Western blot analysis of extracts of rat skin, using TYR antibody.
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.
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et al,Discovery of a Novel Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2) and Cyclin-Dependent Kinase 4 (CDK4) Dual Inhibitor for the Treatment of Triple-Negative Breast Cancer
, (2022),
PMID:
Yes
