产品详情
产品名称NOD2 Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
免疫原描述Recombinant fusion protein of human NOD2 (NP_071445.1).
标记Unconjugated
别名NOD2;ACUG;BLAU;BLAUS;CARD15;CD;CLR16.3;IBD1;NLRC2;NOD2B;PSORAS1;YAOS
数据库入口号Uniprot:Q9HC29
GeneID:64127
Uniprot
Q9HC29
Gene ID
64127
计算分子量22kDa/112kDa/115kDa
实际分子量100KDa
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using NOD2 Rabbit pAb.
Immunohistochemistry of paraffin-embedded human colon using NOD2 Rabbit pAb.
Immunofluorescence analysis of HeLa cells using NOD2 Rabbit pAb.
Immunofluorescence analysis of NIH/3T3 cells using NOD2 Rabbit pAb.
Immunofluorescence analysis of PC-12 cells using NOD2 Rabbit pAb.
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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et al,Pyroptosis-associated genes and tumor immune response in endometrial cancer. In Discov Oncol on 2024 Sep 12
by Xiaodi Gong, Zhifeng Wang,et al..PMID:39264524
, (2024),
PMID:
39264524
et al,H3K18 lactylation-mediated nucleotide-binding oligomerization domain-2 (NOD2) expression promotes bilirubin-induced pyroptosis of astrocytes.
, (2025),
PMID:
40075479
Yes
