产品详情
产品名称TERT Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC
种属反应性Human;Mouse
免疫原描述A synthetic peptide of human TERT (NP_937983.2).
标记Unconjugated
别名TERT;CMM9;DKCA2;DKCB4;EST2;PFBMFT1;TCS1;TP2;TRT;hEST2;hTRT
数据库入口号Swiss Prot:O14746
GeneID:7015
Uniprot
O14746
计算分子量88kDa/90kDa/120kDa/126kDa
配方Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:2000 - 1:5000
IHC 1:50 - 1:200
Immunohistochemistry of paraffin-embedded human breast cancer using TERT at dilution of 1:100 (40x lens).
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
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et al,CENPF (+) cancer cells promote malignant progression of early-stage TP53 mutant lung adenocarcinoma.
, (2025),
PMID:
40044674
Yes
