产品详情
产品名称GRIN2B Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
免疫原描述A synthetic peptide of human GRIN2B (NP_000825.2).
标记Unconjugated
别名GRIN2B;EIEE27;GluN2B;MRD6;NMDAR2B;NR2B;hNR3
数据库入口号Uniprot:Q13224
GeneID:2904
Uniprot
Q13224
Gene ID
2904
计算分子量166kDa
实际分子量190KDa
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using GRIN2B Rabbit pAb.
Immunohistochemistry of paraffin-embedded mouse brain using GRIN2B Rabbit pAb.
Immunofluorescence analysis of Neuro-2a cells using GRIN2B Rabbit pAb.
Immunofluorescence analysis of SH-SY5Y cells using GRIN2B Rabbit pAb.
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
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et al,Site-specific seeding of Lewy pathology induces distinct pre-motor cellular and dendritic vulnerabilities in the cortex
, (2024),
PMID:
Yes
