产品详情
产品名称STING / TMEM173 Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IF
种属反应性Human;Mouse;Rat
免疫原描述Recombinant fusion protein of human STING / TMEM173 (NP_938023.1).
标记Unconjugated
别名TMEM173;ERIS;MITA;MPYS;NET23;SAVI;STING;hMITA;hSTING
数据库入口号Swiss Prot:Q86WV6
Gene ID:340061
Uniprot
Q86WV6
Gene ID
340061
计算分子量42kDa
实际分子量37kDa/38kDa
配方Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using STING \ TMEM173 antibody.
Western blot analysis of extracts of various cell lines, using STING \ TMEM173 antibody.
Immunofluorescence analysis of L929 cells using STING \ TMEM173 antibody.
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.
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et al,Nucleus-targeted ruthenium(II) complex triggers immunogenic cell death and sensitizes melanoma to anti-PD-1 therapy by activating cGAS-STING pathway.
, (2025),
PMID:
40022761
Yes
