产品详情
产品名称IGF2BP3 Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
免疫原描述Recombinant fusion protein of human IGF2BP3 (NP_006538.2).
标记Unconjugated
别名IGF2BP3;CT98;IMP-3;IMP3;KOC;KOC1;VICKZ3
数据库入口号Swiss Prot:O00425
GeneID:10643
Uniprot
O00425
计算分子量21kDa/63kDa
实际分子量70kDa
配方Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:1000
IHC 1:50 - 1:200
IF 1:50 - 1:100
IP 1:20 - 1:50
Western blot analysis of extracts of various cell lines, using IGF2BP3 at 1:1000 dilution.
Immunofluorescence analysis of L929 cells using IGF2BP3 at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded rat testis using IGF2BP3 at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse testis using IGF2BP3 at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human liver using IGF2BP3 at dilution of 1:100 (40x lens).
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.
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et al,Necroptosis-Related Prognostic Model for Pancreatic Carcinoma Reveals Its Invasion and Metastasis Potential through Hybrid EMT and Immune EscapeInBiomedicinesOn2023 Jun 16byHaichuan Liu?1,?Zhenghang Li et al..PMID:?37371833
, (2023),
PMID:
37371833
et al,Depletion of the N6-Methyladenosine (m6A) reader protein IGF2BP3 induces ferroptosis in glioma by modulating the expression of GPX4. In Cell Death Dis on 2024 Mar 1 by Limei Deng, Yunbo Di,et al..PMID:38429265
, (2024),
PMID:
38429265
Yes
