产品详情
产品名称C8orf4 Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC
种属反应性Human;Mouse;Rat
免疫原描述Recombinant fusion protein of human C8orf4 (NP_064515.1).
标记Unconjugated
别名C8orf4;TC-1;TC1
数据库入口号Swiss Prot:Q9NR00
GeneID:56892
Uniprot
Q9NR00
计算分子量12kDa
配方Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Immunohistochemistry of paraffin-embedded rat lung using C8orf4 at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using C8orf4 at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse lung using C8orf4 at dilution of 1:100 (40x lens).
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.
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