产品详情
产品名称LILRB4 Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
免疫原描述Recombinant fusion protein of human LILRB4 (NP_001265355.2).
标记Unconjugated
别名LILRB4;CD85K;ILT-3;ILT3;LIR-5;LIR5
数据库入口号Swiss Prot:Q8NHJ6
Gene ID:11006
Uniprot
Q8NHJ6
Gene ID
11006
计算分子量49kDa
实际分子量49KDa
配方Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using LILRB4 antibody.
Immunohistochemistry of paraffin-embedded human liver cancer using LILRB4 Rabbit pAb.
Immunohistochemistry of paraffin-embedded human colon carcinoma using LILRB4 Rabbit pAb.
Immunofluorescence analysis of mouse spleen using LILRB4 Rabbit pAb.
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
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et al,Spatial transcriptomics reveals prognostically LYZ+ fibroblasts and colocalization with FN1+ macrophages in diffuse large B-cell lymphoma.
, (2025),
PMID:
39998673
Yes
