产品详情
产品名称CTSC Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB
种属反应性Human;Mouse;Rat
免疫原描述Recombinant fusion protein of human CTSC (NP_001805.3).
标记Unconjugated
别名CTSC;CPPI;DPP-I;DPP1;DPPI;HMS;JP;JPD;PALS;PDON1;PLS
数据库入口号Uniprot:P53634
GeneID:1075
Uniprot
P53634
Gene ID
1075
计算分子量15kDa/51kDa
实际分子量70kDa
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
Western blot analysis of extracts of various cell lines, using CTSC antibody.
This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.
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et al,CTSC Overexpression Drives Neutrophil Extracellular Traps And Exacerbates Lung Inflammation in Acute Lung Injury
, (2024),
PMID:
Yes
