产品详情
产品名称Recombinant human Bcl-2-like protein 1
来源种属E.coli
基因/蛋白名称B2CL1
别名Apoptosis regulator Bcl-X
数据库入口号Uniprot ID: Q07817
Uniprot
Q07817
计算分子量39.4kD
配方20mM Tris-HCl based buffer,pH8.0
保存Store at -20˚C, for extended storage, conserve at -20˚C or -80˚C. Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.
Target种属HUMAN
Target长度Partial of the full length of 1-233aa, 1-209aa
应用详情
Purity: Greater than 90% as determined by SDS-PAGE.
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial mbrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial mbrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles.Isoform Bcl-X(S) promotes apoptosis.
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15-30工作日
