产品详情
产品名称Recombinant mouse Baculoviral IAP repeat-containing protein 5
来源种属E.coli
基因/蛋白名称BIRC5
别名Apoptosis inhibitor 4;Apoptosis inhibitor survivin;TIAP
数据库入口号Uniprot ID: O70201
Uniprot
O70201
计算分子量32.3kD
配方20mM Tris-HCl based buffer,pH8.0
保存Store at -20˚C, for extended storage, conserve at -20˚C or -80˚C. Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.
Target种属MOUSE
Target长度Full length, 1-140aa
应用详情
Purity: Greater than 90% as determined by SDS-PAGE.
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movent to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7 .
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15-30工作日
