产品详情
产品名称Recombinant human Complement C5
来源种属E.coli
基因/蛋白名称CO5
别名C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
数据库入口号Uniprot ID: P01031
Uniprot
P01031
计算分子量24.27kD
配方20mM Tris-HCl based buffer,pH8.0
保存Store at -20˚C, for extended storage, conserve at -20˚C or -80˚C. Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.
Target种属HUMAN
Target长度Full length of C5a anaphylatoxin chain, 678-751aa
应用详情
Purity: Greater than 90% as determined by SDS-PAGE.
Activation of C5 by a C5 convertase initiates the spontaneous assbly of the late complent components, C5-C9, into the mbrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assbled.Derived from proteolytic degradation of complent C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes . C5a is also a potent chokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
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15-30工作日
