产品详情
产品名称Recombinant human Cyclin-dependent kinase inhibitor 1
来源种属E.coli
基因/蛋白名称CDN1A
别名CDK-interacting protein 1Melanoma differentiation-associated protein 6 ;MDA-6p21
数据库入口号Uniprot ID: P38936
Uniprot
P38936
计算分子量45.5kD
配方20mM Tris-HCl based buffer,pH8.0
保存Store at -20˚C, for extended storage, conserve at -20˚C or -80˚C. Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.
Target种属HUMAN
Target长度Full length, 2-164aa
应用详情
Purity: Greater than 90% as determined by SDS-PAGE.
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assbly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
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15-30工作日
